Remember a piece of news reported by Guangming.com? An 18-year-old girl in Guangdong lost her young life because of taking both roxithromycin and compound methoxyphenamine capsules during a cold.
Among them, roxithromycin is an antibiotic drug, which is often used to treat various inflammations, such as tonsillitis, otitis media, skin infections, etc.; if you have a cough or phlegm after a cough, you can choose Compound methoxyphenamine capsules this drug to treat. (Purchased under the guidance of a doctor)
However, In clinical practice, these two drugs cannot be taken at the same time, the latter drug contains theophylline >, if taken together, the two drugs will interact with each other and inhibit the metabolism of the drug in the body.
The early symptoms of aminophylline poisoning are restlessness, nausea, vomiting, dizziness, headache, tinnitus, etc. Symptoms such as coma, severe cases can lead to death due to pulmonary edema, cerebral edema, and respiratory paralysis.
It can be seen that medication safety is an aspect that we need to pay more attention to and pay more attention to. Physically, even life-threatening!
What other drugs should be avoided when taking roxithromycin, a common antibiotic drug, and should not be taken with it? And in life, what other common “drugs” should not be mixed together?
1. Reminder: When taking roxithromycin, it is not recommended to mix with these drugs!
Roxithromycin belongs to a class of over-the-counter drugs and can be bought in pharmacies. It is a commonly used antibiotic drug prepared by almost every family. It is suitable for all kinds of inflammation caused by bacteria. It can be divided into different types, such as roxithromycin capsules, roxithromycin enteric-coated tablets, roxithromycin dispersible tablets, etc.
It is mainly used to treat inflammations, such as pharyngitis, otitis media, sinusitis, pneumonia, bronchitis, etc. For those who have these inflammations in the body, and the inflammation is easy to recur, doctors often It is recommended to take roxithromycin.
Roxithromycin, a new generation of macrolide antibiotics, is often used to treat many different types of infections caused by susceptible bacteria, such as Upper and lower respiratory tract infections, ENT infections, genital infections and skin infections. It can be seen that its scope of application is very wide.
Using the right medicine can cure the disease and save people, but if it is wrongly used, it will bring no harm! Therefore, when taking roxithromycin, you should pay attention to avoid taking the following drugs together, otherwise your body will have some serious adverse reactions, and even threaten your own life and health!
1. Roxithromycin cannot be taken with the antiarrhythmic drug amiodarone.
Amiodarone is a drug used to treat irregular heart rhythms and arrhythmias. During the period of taking amiodarone, taking roxithromycin to treat inflammation in the body, such as otitis media, pharyngitis, etc., will prolong the QT interval of the patient’s electrocardiogram.
This value can reflect the speed of the patient’s heart rhythm. If QT interval prolongation, it means slow heart rhythm, will cause the patient to take the medicine. The blood supply to the heart is insufficient, resulting in dizziness, fatigue, chest tightness, shortness of breath, amaurosis, and even sudden fainting.
2. Roxithromycin cannot be taken with sedative-hypnotic midazolam
Midazolam, with anti-anxiety, sedative, and hypnotic effects, is commonly used in the treatment of insomnia and in inducing sleep during surgical examinations. If taken together with roxithromycin, it will inhibit the metabolic efficiency of midazolam in the human body, which will lead to an increase in the blood concentration of midazolam and increase the incidence of adverse reactions in the body.
3. Roxithromycin cannot be taken with gastric motility drug cisapride
cisapride, which is usually used to treat chronic Severe gastrointestinal motility diseases with poor tolerance or poor efficacy can promote gastrointestinal emptying and improve esophageal clearance.
However, patients with gastrointestinal diseases must not take roxithromycin during the period of taking such drugs, otherwise the user is very likely to have arrhythmia, arrhythmia and other conditions, dizziness, Difficulty breathing, chest tightness, shortness of breath and other symptoms.
4. Roxithromycin should not be taken with ketoconazole, a skin disease drug
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Usually, these drugs are used by patients with moss hand, foot moss, body moss, variegated moss, etc. At the same time, it is also used to treat diseases such as dandruff.
If roxithromycin is taken when using this type of drug, it will aggravate the damage to the liver in the body, bring stronger drug toxicity, and increase the burden on the liver at the same time. , may also lead to severe hepatic insufficiency.
Therefore, if you are taking other medicines while taking roxithromycin capsules, please consult your doctor first, and use the medicine rationally under the guidance of a doctor.
Second, in addition to roxithromycin, don’t mix these with them, there is a risk of death!
In fact, there are still some drug taboos and misunderstandings in life, which also bring the same tragedy because they are ignored or ignored by many people. The following are several common drug “minefields”, I hope you will avoid them consciously after seeing them!
Contraindicated combination 1: antihypertensive drugs + grapefruit juice
Patients with hypertension should pay attention when taking antihypertensive drugs, some antihypertensive drugs cannot be combined with grapefruit juice. “Same food”, for example, felodipine, nifedipine, etc.
Because grapefruit contains furanocoumarin, furanocoumarin and many antihypertensive drugs are metabolized by the CYP3A4 enzyme system, the former competitively inhibits the activity of CYP3A4, which increases the blood concentration of antihypertensive drugs. Several times or even dozens of times as usual, a series of side effects are induced, and the common one is lowering of blood pressure.
Contraindication combination 2: Aspirin + Ginkgo biloba drugs
Patients taking aspirin must be Remember not to take with ginkgo biloba drugs, such as ginkgo biloba and other drugs.
Ginkgo biloba drugs, mainly Chinese patent medicines made from Ginkgo biloba extracts, have the effects of activating blood circulation and removing blood stasis, dredging blood vessels and soothing collaterals, etc., and also have anti-platelet aggregation effects . If both are taken at the same time, or taken within a short period of time, it will increase the risk of bleeding in organs such as the heart and brain.
Contraindication Combination 3: Cold Medicine + Honey
Some people, especially children, After taking the cold medicine, if you feel your mouth is bitter, you will drink some honey water to eliminate the bitter medicine taste in your mouth, but this is not advisable.
Honey contains fructose, glucose, digestive enzymes and other substances. If a cold medicine is mixed with honey, enzymes in honey will affect the ingredients in the cold medicine, a certain chemical reaction will occur, reduce the efficacy of the medicine, and it is not conducive to the disease. get better.
Contraindication Combination Four: Cephalosporin + Huoxiangzhengqi Water
cephalosporin antibiotics, if combined with Taking alcohol-containing foods or medicines together will cause a “disulfiram-like reaction”, which is simply ethanol poisoning.
In mild cases, symptoms such as dry mouth, sweating, and flushing may occur, and in severe cases, difficulty breathing, palpitation, dizziness, headache, nausea and vomiting , chest tightness, shortness of breath, decreased blood pressure and other symptoms, and even some people may experience shock reaction.
Third, after taking roxithromycin, be alert to the following adverse reactions!
Although roxithromycin has many functions and effects, there are many indications, and the curative effect is definite. However, many people are still more or less resistant to antibiotics including erythromycin, thinking that after taking such drugs, the body will have adverse reactions.
But in fact, no matter it is any drug, there is a certain toxicity. After taking it, it will cause drug toxicity and harm to various organs of the body, thus causing a series of adverse reactions. However, if you follow the doctor’s advice when taking it, and do not adjust the dosage and course of treatment without authorization, the harm of the drug to the body will be minimal.
What are the common adverse reactions in patients with inflammation when taking roxithromycin?
Gastrointestinal adverse reactions, common in most users. Many people’s gastrointestinal tract will be disordered, and digestive dysfunction will occur, mainly manifested as nausea, retching, vomiting, stomach pain, diarrhea, etc. This is a medical reaction associated with receiving antibiotic treatment, caused by an imbalance in the normal gut flora.
Constipation, is also a common adverse reaction after taking roxithromycin. It is related to the chemical reaction of antibiotics in the human body, which causes the body to have symptoms such as difficulty in defecation, dry stool, and unclean defecation.
And some people take roxithromycin, the liver and bile ducts and other organs will be stimulated, resulting in abdominal pain, body fever, mild hepatomegaly and other symptoms, which is also one of the more typical Adverse reactions.
In addition, there is a special group of people to pay attention to, that is, people who are allergic to roxithromycin. For this group of people, taking roxithromycin will cause varying degrees of overdose.Allergic reactions, mainly manifested as skin and mucous membrane reactions, such as skin redness, itching, swelling, etc., in severe cases, difficulty in breathing, and even lethal shock Wait.
Because of every person’s physique, diseases, and doses of medicines that are different, after taking roxithromycin, there will be different levels of different adverse reactions.
If the above adverse reactions are found in the body, it is recommended to seek medical treatment in time. Don’t take it for granted that this is a normal reaction, and it will disappear on its own after a few days. If minor adverse reactions are not controlled in time and effectively, they will lead to serious physical diseases.
Warm reminder
In life, there is another combination, everyone should be vigilant, that is, disinfectant and toilet cleaner. For taboo combinations.
If the toilet cleaner and 84 disinfectant are used at the same time when cleaning the toilet, toxic chlorine gas will be generated in the air, and enter the human body through the respiratory tract, damage the respiratory mucosa, cause inflammation, and in severe cases will breathe difficult, even fatal.
[1] “Mixing these drugs can be fatal”, Center for Drug Evaluation, 2021.8.31.
[2] “Take Roxithromycin for Throat Inflammation? You need to know these 5 major adverse reactions”, Science Popularization of Rational Drugs, 2019.9.27
[3] “18-year-old girl died after taking two kinds of cold medicines together. Taking these medicines together may lead to death! “, Guangming.com, 2022.2.10.