What happened to those infected with the new crown? British study of 600,000 people reveals data

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What happened to those who contracted Covid-19?

April 12, Imperial College London, UK published in the journal Nature Communications. This study surveyed more than 600,000 British community populations by random sampling to calculate the nationally representative prevalence of COVID-19 sequelae in the population and the mainstream sequelae symptoms, and the risk of sequelae. Factors were assessed in the hope of providing more information to clinicians and the public.

span>1. Some people still have 1 symptom 3 months after the first symptom onset

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Symptoms reported with COVID-19 include severe fatigue, difficulty breathing,chest pain or heaviness, fever, heart palpitations, loss of smellloss, loss of taste, rash and joints pain or swelling.

Among the 92,116 COVID-19 antibody-positive people in the main analysis cohort, 37.7% were still alive after the 12th week of the first symptom onset. More than one symptom was present, and 17.5% still had three or more symptoms. In the repeat cohort, 21.6% of COVID-19 antibody-positive individuals reported having more than one symptom 12 weeks after their first symptom onset, and 11.9% had more than three symptoms. (The sample involves time 2020year9month-2021 year2monthand2021year5month)

2. The sequelae are mainly fatigue and shortness of breath, and severe cases are more prone to respiratory-related sequelae

There are two main groups of people with sequelae of COVID-19 in the main analysis cohort. The main symptoms of group 1 are fatigue, accompanied by muscle aches, difficulty sleeping, and shortness of breath; group 2 is mainly characterized by respiratory symptoms, such as shortness of breath, chest tightness and chest pain.

Statistical analysis shows that patients with severe symptoms and hospitalization during infection are more likely to have respiratory-related sequelae after discharge.

In addition, people hospitalized with COVID-19 are 3.45 times more likely to suffer from COVID-19 sequelae than non-hospitalized people, but it is a little surprising that Asian populations The risk of COVID-19 sequelae is 16% lower than that of Caucasians. ①②

Again! The new crown is not a big flu!

Some people think that the infection symptoms of Omicron are very mild, which is basically equivalent to a large flu. The existing epidemic prevention measures Overly strict, Liang Wannian, head of the expert group of the National Health and Health Commission’s Epidemic Response and Disposal Leading Group, said in a CCTV news interview on April 23 that the severity of Omicron is far higher in terms of transmission speed and case fatality rate. As for influenza, once the prevention and control is relaxed, it will cause a large number of severe illness and death.

Omicron is far more transmissible than influenza and other previous variants of the new crown. In the absence of protective measures, a person can transmit an average of 9.5 people. From the perspective of the case fatality rate, the average case fatality rate of influenza in the world is 0.1%, and the case fatality rate of the Omicron variant, real-world data shows that the average case fatality rate It is about 0.75%, which is about 7 to 8 times that of influenza. The fatality rate of the elderly, especially those over 80 years old, exceeds 10%, which is nearly 100 times that of ordinary influenza.

Liang Wannian said that from the actual point of view of our country, our elderly population is huge, coupled with the current elderly population, the vaccination rateIt has not reached the point where it is sufficient to form such an immune barrier against severe illness and death. There are still so many children and so many immunocompromised people in China, because they have various contraindications, and some people have not been vaccinated. In this case, once we’re going to relax, leave it alone, the prospect of it can be clearly seen, and it’s definitely spread widely. Once these people are infected, multiplying his case fatality rate and his severe illness rate, I think it will cause a lot of severe illness and death. This number is huge, and it is also a huge disaster for a country and a nation.

Liang Wannian said that if a large number of severe cases occur, it will in turn run on the medical system, which will inevitably lead to the unmet demand for normal medical services. , forming a vicious circle, and ultimately widely affecting people’s normal production and life.

actively vaccinated, Prevention of becoming severe A sex analysis study describing the association of Covid-19 vaccination with clinical severity in patients infected with delta or Omicron variants.

The study is based on data from the National Notifiable Disease Reporting System and the National Immunization Program Information System for the period May 21, 2021 to February 2022 Analysis of new coronary pneumonia surveillance and vaccination data during the 28th. During the period, there were a total of 10,829 cases of new coronary pneumonia in China, of which 8,675 were caused by the delta variant and 2,154 were caused by the Omicron variant.

Research shows that vaccination with domestically produced new coronavirus vaccine can increase the risk of pneumonia infection with delta variant strains Reduced by 50%-70%, reducing the risk of severe new coronary pneumonia in adults by 70%-80%. The risk of pneumonia after booster vaccination was reduced by 86% and the risk of developing severe disease was reduced by 91%-98%; and the risk of developing pneumonia after vaccination in adults 60 years and older was reduced by 70%- 80% of people aged 60 and over who received booster shots had no severe cases of Omicron.

However, the study also mentioned that this only reflects the relationship between vaccination and the risk of disease development, not a direct measure of vaccine effectiveness. Metrics. ④⑤

Director of Shanghai Municipal Health Commission Wu Jinglei also appealed at the press conference on the new crown epidemic in Shanghai on April 17 that if the chronically ill people who take regular medication are not in the acute exacerbation period, or the condition is well controlled and in a stable period, they can be vaccinated. Inoculate the vaccine as soon as possible after the closure and the nearby vaccination points are opened, and strengthen the vaccination as soon as possible after the whole vaccination is completed for 6 months, so as to produce better results.

This article is synthesized from:① Whitaker, M., Elliott, J., Chadeau-Hyam, M. et al. Persistent COVID-19 symptoms in a community study of 606,434 people in England. Nat Commun 13, 1957 (2022). https://doi.org/10.1038/s41467- 022-29521-z② 2022-04-24 Metz Medicine (ID: MedSci_cn) “Data of 600,000 people revealed that there are two types of people with sequelae of the new crown: one is fatigue, the other is gas Shortness of breath, chest tightness (mostly severe)”③ 2022-04-23 CCTV News “Liang Wannian: Omikron is not a big flu”④ Association of COVID-19 Vaccination and Clinical Severity of Patients Infected with Delta or Omicron Variants — China, May 21, 2021–February 28, 2022https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2022. 074⑤ 2022-04-09 Health Times “China Disease Control Weekly Report: No Omicoron Severe Severity in Elderly Vaccinated with Booster”⑥ 2022-04-17 Shanghai New Coronary Pneumonia Epidemic Prevention and Control Press Conference

Editor: Ren Xuan

Reviewer: Yang Xiaoming span>

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