Case:
63-year-old Ms. Zhang has cardiovascular disease and has been taking digoxin.
A few nights ago before going to bed, she prepared to take medicine as usual. Just thinking that the milk soaked on the side has not been drunk yet, so I took it with milk. But soon after, she developed symptoms such as palpitations, dizziness and abnormal heart beating, and her family rushed her to the hospital.
After examination, Ms. Zhang had a serious arrhythmia. Fortunately, she was sent to the doctor in time. Serious complications can occur.
Didn’t you just drink a glass of milk? How could it be so serious?
In fact, there is no problem whether drinking milk or eating digoxin, the key is that the two cannot be put together~
Drugs and food take the “same path” in the human body. If the two cooperate well, the efficacy of the medicine can be enhanced. If improperly coordinated, it will not only affect the efficacy of the medicine, but even produce toxic and side effects. In severe cases Can be life-threatening!
Today, Coco has counted some foods and medicines that will “fight each other”, but you must Remember clearly!
1. Milk< /p>
Especially not suitable for taking these drugs
Milk nutrition It is rich, not only beneficial to the growth and development of teenagers, but also helping middle-aged and elderly people to prevent osteoporosis, so it has become a daily drink for many people, and some people even take medicine with milk. But cocoa is really not recommended:
On the one hand, milk can form a film on the surface of the drug and the gastric mucosa, and when the film is After digestion and absorption, the drug has missed the optimal absorption period, thus reducing the absorption and efficacy of the drug.
On the other hand, metal ions such as calcium and magnesium contained in milk may chemically react with drugs, not only Destroying the active ingredients in the medicine may also increase the toxicity of the medicine.
Especially the following 6 drugs are more likely to “collide” with milk :
1. Antacids
such as bismuth potassium citrate, compound bismuth aluminate, colloidal bismuth pectin, etc. antacids that protect the gastric mucosa, and milk Concomitant administration will not only affect the efficacy of the medicine, but may also cause milk-alkali syndrome and varying degrees of renal function damage.
2. Antibacterial drugs< /span>
Such as quinolones, tetracyclines, oxytetracycline, erythromycin, metronidazole, etc.. Metal ions in milk can form chelates that are not easily absorbed with these drugs, thereby reducing the efficacy of the drugs, and even making the drugs completely ineffective.
3. Cardiac medicine
Milk The calcium contained in it can enhance the toxicity of digitalis and digoxin cardiotonic drugs, easily cause accumulative toxic reactions of the drugs, and even may lead to heart failure< /strong>.
4. Antihypertensive drugs
Milk is rich in tyramine, but antihypertensive drugs can inhibit the enzyme that breaks down tyramine in the body, which may lead to tyramine in the body Accumulate, even stimulate vasoconstriction, cause blood pressure rise, heart rhythm disorder, and hypertensive crisis may occur in severe cases.
5. Antidiarrheal medicine
Milk contains The lactose component in Lactose can not only reduce the efficacy of antidiarrheal drugs, but also aggravate diarrhea symptoms.
Prompt< /strong>: Except for the special circumstances ordered by the doctor, It is best to take the medicine with plain water, and do not drink milk or dairy products for two hours before and after taking the medicine .
Second, some fruits and some medicines are also “dead enemies”< /span>
① Grapefruit< /span>
Pomelo fruit, especially the naringenin, bergamotin, furanocoumarin and other components contained in grapefruit, It will inhibit the activity of drug-metabolizing enzymes, thereby prolonging the residence time of the drug in the body and increasing the drug concentration in the blood, which may cause the drug to be too effective and cause adverse reactions span>.
Which drugs are specifically metabolized by grapefruit?
1. Statins< /span>
Statin lipid-lowering drugs, such as simvastatin, atorvastatin, lovastatin, etc. Eating grapefruit while taking the medicine may cause rhabdomyolysis, muscle pain and other symptoms. And 30% of patients with rhabdomyolysis will develop acute renal failure.
2. Antihypertensive drugs
especially calcium antagonist antihypertensive drugs ,Including nifedipine, felodipine, amlodipine, lacidipine, etc., and then eating grapefruit, like an overdose, may cause a sudden drop in blood pressure, and at least cause Dizziness, palpitation, fatigue, and severe angina pectoris, myocardial infarction or stroke.
3. Sedative and hypnotics
Grapefruit will prolong diazepam, midazolam, etc. Increasing dizziness, lethargy, fatigue and other adverse reactions, the next day after taking the medicine, you may also have “hangover” symptoms (such as dizziness, etc.). Therefore, workers at heights and drivers Pay special attention to during medication.
4. Immunosuppressants
Grapefruit can increase the plasma concentration of immunosuppressants such as cyclosporine, and increase liver and kidney toxicity , increase the incidence of hypertension, diabetes, hyperkalemia, etc.
Prompt : There are as many as 85 kinds of drugs that can react with grapefruit and pomelo fruits, and the easiest way to identify them is to read the drug instructions. Take“, try not to eat this kind of fruit during the medication.
② Banana
Banana is also a commonly eaten fruit. Not only is it more affordable, but it also contains almost all vitamins and minerals. Not suitable for food with the following drugs:
1. Quinolones Antibacterials
Ciprofloxacin, Oxygen Flufloxacin, enoxacin and other quinolones are more sensitive to minerals. Bananas contain more minerals such as potassium, magnesium, and iron, which may reduce the bioavailability of these drugs.
In addition, the serotonin contained in bananas can reduce gastric acid levels, which may also interfere with the absorption process of such drugs, and ultimately affect their efficacy play.
2. Potassium-sparing diuretics
Spironolactone, triamterene, amiloride and other potassium-sparing diuretics promote sodium Ion and water discharge.
The potassium content in bananas is relatively high, reaching 380-420mg/hectogram, if Eating too much may cause hyperkalemia, fatigue and numbness of limbs.
3. Antihypertensive drugs< /span>
There are many potassium ions in bananas, which can control the blood pressure caused by high sodium. It is best to eat less or not to eat bananas, so as not to adjust the medicine in place.
③ Persimmon
We all know , persimmons contain tannic acid, eating too much or eating persimmons on an empty stomach may cause discomfort. And this tannic acid may also react with some drugs, including:
1. Supplement Iron
Tannic acid is easy to react with iron, forming precipitation of iron tannin, which affects iron ions Absorption.
2. Calcium-supplementing drugs
Such as calcium gluconate tablets, calcium lactate granules, etc. Tannic acid protein in persimmon combines with calcium, which is easy to form stones , can also affect calcium absorption.
④ Vegetables and fruits high in vitamin K
1 , Anticoagulant drugs
Anticoagulant drugs like warfarin inhibit liver cells by acting against vitamin K Synthetic coagulation factors, etc., play the role of anticoagulation and antiplatelet aggregation.
Vitamin K is an antagonist of warfarin, so you should limit foods high in vitamin K when taking the medicine , including celery, coriander, kiwi, apple, etc., do not eat too much, so as not to increase the risk of blood clots.
Third, when taking the third class of drugs, don’t put vinegar in cooking
Put some vinegar in cooking, and dipping in vinegar when eating dumplings and steamed buns are common practices, both appetizing and digestive. However, it is best not to be jealous when taking the following medicines:
1. Gastric acid drugs
The main ingredients of drugs such as Weishuping and Daxi are sodium bicarbonate, calcium carbonate, aluminum hydroxide and other alkaline substances to neutralize stomach acid and relieve stomach discomfort.
And Acetic acid can react with alkaline substances, directly reducing the properties of these drugs, eating too much will stimulate gastric acid secretion, which is not conducive to the condition control.
< span>2. Sulfa drugs
After the decomposition of these drugs, the acetylated sulfonamides and a small amount of glucuronic acid are combined The substance is in a crystalline state with low solubility, which can cause crystalluria, hematuria and even urinary tract obstruction, leading to kidney damage.
3. Aminoglycoside antimicrobials< /span>
The antibacterial effects of streptomycin, kanamycin, gentamycin, etc.are stronger in alkaline conditions, but less so in acidic environments Reduce the properties of the medicine. In addition, acidic food will also accelerate the excretion of this kind of medicine, which is equivalent to letting the antibacterial medicine “retire early”, and has not finished the work of eliminating bacteria.
Tips:< /span> Not only vinegar, try not to eat sour foods such as hawthorn and dark plum within 1~2 hours before and after taking the above drugs.
Medicine is no small matter, you must read the instructions more before taking the medicine, no matter the time, dosage, contraindications, you need to know in advance, if you are not sure, you can Ask a specialist doctor.