Lao Zhang went to the hypertension clinic for a follow-up visit, and told the doctor: “I have been taking amlodipine for more than half a year. Drug resistance, can you give me another one?” Can antihypertensive drugs really produce drug resistance?
Drug resistance refers to the body’s tolerance to drugs or Resistance, it is necessary to increase the dose or increase the frequency of administration to achieve the therapeutic purpose.
Sometimes even with reasonable use of antihypertensive drugs, blood pressure in hypertensive patients still fluctuates. This is because there are many reasons for blood pressure fluctuations, such as unhealthy lifestyles, seasonal changes, co-administration of other drugs or multiple diseases, etc. It is not that antihypertensive drugs are resistant. There are five commonly used antihypertensive drugs—calcium channel blockers (CCBs), diuretics, beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor antagonists ( ARB), generally do not cause drug resistance.
Many hypertensive patients hope that antihypertensive drugs will have “immediate results”, but they do not know that an excessive drop in blood pressure in a short period of time can cause adverse consequences. Antihypertensive is long-acting and stable. Generally, the adjustment time of antihypertensive drugs is 2-4 weeks, so the medication should be persisted for a long time, and it is not allowed to eat and stop, or change at will. However, if there are intolerable adverse reactions, seasonal changes make it difficult to control blood pressure, or changes in the disease state, it is necessary to see a doctor in time to adjust the drug.
Source: Medicine Gourd Baby