Is Sinovac inactivated vaccine associated with risk of pulmonary nodules? It’s not strictly speaking!

The night before yesterday, a colleague of mine in the hospital asked me, is it true that it is said on the Internet that the Sinovac vaccine will cause lung nodules?

She was worried because she also found a lung nodule for the first time during her physical examination this year.

I went to great lengths to explain it to her, but fortunately she came from a medical background, so it was relatively easy to explain.

We know that any drug will have side effects, and there will be adverse effects. If a vaccine is used as a drug, if it does not have any side effects and adverse reactions, it will definitely have no effect.

Therefore, it is normal for Sinovac vaccines to have some side effects and adverse reactions.

Kexing vaccine is the inactivated vaccine of the new coronavirus, which contains the virus protein shell of the new coronavirus that has been extinguished.

As a foreign protein component, although it has been technically processed, it will not cause allergic reactions to most people, but it can also cause allergic reactions in certain groups of people, such as people with allergic constitution. of.

Thus, one of the most common side effects of any vaccine containing foreign protein components is allergic reactions.

However, Sinovac vaccines cover up all the side effects and adverse reactions strictly and never announce it, which is really hard to agree with.

Rumours are born of obscurity, and they are born of opacity. The best way to respond to rumors is to be open and transparent.

If Sinovac vaccines can directly disclose the data of the third phase of the vaccine, it is the best way to respond to the rumors. Also the most convincing.

There are too many rumors about Sinovac vaccines on the Internet. Sometimes I don’t want to speak, because Sinovac has done a bad job in publicity and is not authentic.

Mourning for his misfortune, anger for not fighting.

Let me talk about whether the Sinovac vaccine will cause lung nodules.

Pulmonary solid nodule means a round, localized solid shadow with increased density and uniform density, which is commonly seen in inflammatory hyperplasia, pulmonary tuberculosis, foreign body granulomas such as pneumoconiosis, Lung tumors, etc.

Inflammatory nodules are mainly nodules caused by infection with pathogens such as viruses, bacteria, mycoplasma, fungi, etc. The Kexing vaccine has been inactivated and cannot infect the human body, resulting in this infectious lung disease nodules.

Foreign body granuloma, like pneumoconiosis, is formed after a foreign body enters the lung and is wrapped.

The Sinovac vaccine obviously does not have this effect either.

The remaining question is whether the Sinovac vaccine will cause tumors in the lungs.

Most tumors in the lungs are malignant tumors, also known as lung cancers.

Let’s start with what cancer is.

In layman’s terms, cancer is a piece of flesh in the human body that can grow uncontrollably and indefinitely. In non-solid cancers, such as leukemia, this piece of flesh is distributed throughout the body.

We grow, age, die, and are regulated by genes in our bodies. DNA fragments with genetic information are genes, and genes exist in every cell of our body.

Therefore, our livers look like livers when they grow up, stomachs look like stomachs when they grow up, and lungs look like lungs when they grow up.

When these lung, stomach, and liver cells replicate and divide, and grow to a certain extent, when they grow to the shape that liver or stomach should have, the genes that control their growth will work, and they will not continue. long. These are normal somatic cells.

Our body metabolizes every day, old cells die and new cells divide and reproduce. During the process of cell division and replication, under the action of carcinogenic factors, some DNA fragments will be lost or increased, which leads to the emergence of somatic cells with abnormal DNA.

Most of these abnormal cells will die, some will be killed by the body’s immune system, and a very small part will survive and escape the body’s immune surveillance system. These abnormal cells are no longer restricted in growth due to genetic changes and can grow indefinitely.

At the same time, due to genetic changes, these abnormal cells will also secrete some substances that are toxic to the human body. These substances can interfere with various physiological functions of the human body and cause death.

When these cells grow into a piece of flesh, it is a solid tumor cancer. Cancer grows indefinitely, invades normal organ sites, consumes human nutrients, and secretes toxic substances to poison people. Cancer is the main cause of human death.

Therefore, the carcinogenic factor acts on the human body, and the toxicity to the human body should not be too strong. If the toxicity is too strong, human cells will be poisoned immediately, or if the cells change too much, they will be recognized by the human immune system and killed, and they will not grow into cancer.

Only changes that slightly alter a segment of the body’s DNA can escape the immune system and grow into cancer.

Therefore, the development of cancer in any individual is the result of a combination of genetic and environmental factors, and it often takes a long time.

It takes a long time to screen for cancer cells that have genetic mutations and are still viable.

Lung cancer cells are also based on normal cells, under the action of carcinogenic factors, gradually accumulate mutations, and then the mutated cells continue to proliferate, and finally form mutant cell clones, and then screen out those with the highest malignant transformation rate. Cells continue to proliferate and eventually form lung cancer, which is also a step-by-step development and evolution that requires a period of time for the malignant transformation of cells.

In layman’s terms, normal lung cells need a little change in order to survive just enough to not be attacked by the immune system. Therefore, it takes a long time for normal cells to evolve into lung cancer.

This time, in just a few monthsEvolving into lung cancer, time is not enough. At least 5-10 years.

Even if you have lung cancer and show nodules, the growth is very slow at first, and it takes years to calculate the change.

So, even if he smokes, and a 10-year-old man has a lung nodule 0.5 cm in diameter, we generally don’t think he has lung cancer in the first place.

If (note that if) there is a side effect of lung cancer after the Kexing vaccine, then this lung nodule should appear 5-10 years after vaccination.

In other words, the general population has only received the Sinovac vaccine for more than a year.

Whether the Sinovac vaccine will cause lung cancer depends on the results 5-10 years later.

Because it can be ruled out in time, it can be clearly stated that there is no relationship between the current patients with pulmonary nodules and their vaccination with Sinovac.

Strictly speaking, whether the vaccine will lead to the occurrence of pulmonary nodules, we need to look back in 5 to 10 years.

At present, any conclusion denying or acknowledging the relationship between Sinovac vaccines and pulmonary nodules is not strictly medical.

All we can say is that the current patients with lung nodules have nothing to do with their vaccination with Sinovac.

Lung cancer patients that will appear in 5-10 years will be left to future professionals to study whether it has anything to do with the Sinovac vaccine.