General gouty nephropathy must pay attention to lifestyle adjustments, including screening and active control of cardiovascular disease risks related to hyperuricemia, such as hypertension, diabetes, blood lipids, etc.
If end-stage renal disease occurs later, hemodialysis or peritoneal dialysis should be performed in time.
Adjusting diet, restricting high-purine diet, controlling calorie intake, and avoiding obesity are important links in preventing hyperuricemia and gout.
Drink more water to accelerate the excretion of uric acid.
Drug therapy is best guided by the following principles:
● None Serum uric acid ≥ 420 in gout patients after 3 months of non-drug treatment should be treated with uric acid-lowering drugs
Gout patients with serum uric acid ≥ 360, severe gout patients with serum uric acid ≥ 300 Uric acid-lowering drug therapy.
The goal of lowering serum uric acid: it is recommended for chronic kidney disease patients with gout, serum uric acid <360;
with severe For chronic kidney disease patients with gout (tophi, chronic arthritis, recurrent gout attacks ≥ 2 times/year), it is recommended that serum uric acid <300;
other chronic kidney disease patients, Serum uric acid <420 is generally recommended.
● If taking, such as diuretics (especially thiazides), corticosteroids, insulin, cyclosporine, tacrolimus, nicotine, Pyrazinamide, niacin, low-dose aspirin, etc., these drugs may cause elevated serum uric acid.
● Alkaline urine and maintain urine pH at 6.2~6.9, which is conducive to the dissolution of urate crystals and the release of urine from urine out.