Recent studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and emerging Correlation between increased risk of heart failure (HF). However, the magnitude of the risk of new-onset HF in patients with NAFLD and whether this risk varies with the severity of liver disease remains uncertain. Recently, a meta-analysis published by Gut (impact factor 31.793) assessed the magnitude of the association between NAFLD and the risk of new-onset HF. Results: NAFLD is associated with a 1.5-fold increased long-term risk of new-onset HF regardless of the presence of diabetes, hypertension, and other common cardiovascular risk factors< span>.
Methods
The researchers systematically searched PubMed and other databases from establishment to March 2022. Eligible observational studies diagnosed NAFLD by serum biomarkers/scores, International Classification of Diseases (ICD) codes, imaging, or liver histology. The primary outcome was new-onset HF. Data from selected studies were meta-analyzed using random-effects models.
Results
A total of 11 longitudinal cohorts were included The study pooled data from 11,242,231 middle-aged individuals from different countries, of whom 50.1% were female, with a mean age of 55 years and a mean body mass index (BMI) of 26.4 kg/m2. At baseline, there were 2,944,058 (26.2%) patients with NAFLD, and with a median follow-up of 10.0 years (IQR 8-14 years), 97,716 HF cases were diagnosed.
NAFLD is associated with increased risk of new-onset HF (HR 1.50, 95%CI 1.34-1.67, p<0.0001; I2=94.8%). The risk was independent of age, sex, race, markers of obesity, diabetes, hypertension and other common cardiovascular risk factors. Sensitivity analyses did not alter these results. The funnel plot did not reveal any apparent publication bias.
Figure 1 Forest plot and estimated impact of NAFLD on emerging HF risk
Study Conclusions
whether or not In the presence of diabetes, hypertension, and other common cardiovascular risk factors, NAFLD was all associated with a 1.5-fold increased long-term risk of new-onset HF. The results of this meta-analysis further underscore the need for a patient-centered, multidisciplinary, and holistic approach to the management of liver disease and cardiovascular risk in patients with NAFLD.
References: Mantovani A, Petracca G, Csermely A, Petracca G, Csermely et al. Non-alcoholic fatty liver disease and risk of new-onset heart failure: an updated meta-analysis of about 11 million individuals. Gut. 2022 Jul 25:gutjnl-2022-327672. doi: 10.1136/gutjnl-2022-327672 .