Haloperidol combined with pramipexole in the treatment of Parkinson’s disease with mental disorders

Parkinson’s disease is a disease that is prone to the elderly, and is a degenerative disease of the nervous system. Its clinical manifestations are slow movement, muscle rigidity, and resting tremor. have a great impact on health and quality of life.

Clinical practice has found that most patients with Parkinson’s disease often suffer from depression, sleep disturbance, and cognitive impairmentand other mental disorders, so the clinical treatment of Parkinson’s disease is recommended to focus on improving mental symptoms.


Some scholars said that slow movement, muscle stiffness, gait disturbance, etc. are the main motor symptoms , Neuropsychiatric disorders, sleep disorders, autonomic symptoms, sensory disturbances are all non-motor symptoms.

Studies have shown that Parkinson’s disease is characterized by chronic progress, with varying degrees of mental disorders, not only aggravating the patient’s Mental burden, which also brings mental pressure and economic burden to the family, clinically reducing drugs or improper use of drugs will hinder the recovery process, so choose appropriate drug treatment is the key to effective treatment of the disease.

Drug therapy is the main treatment for this disease clinically, and cloperidol and pramipexole are commonly used drugs. The clinical efficacy of single use has been unanimously recognized by the medical community, but there are few reports on the combined effect.


Pramipexole is a common drug for the treatment of Parkinson’s disease, its mechanism of action is by activating the cortex-frontal cortex, limbic receptors The overall curative effect is better than traditional anti-Parkinson’s drugs, but it is very easy to cause patients listlessness, insomnia, nausea, loss of appetite, etc. The occurrence of adverse reactions is not conducive to the rapid recovery of patients.

In this study, the patients in the observation group took haloperidol on the basis of pramipexole, and obtained a more ideal curative effect.

Haloperidol< /h1>

Haloperidol is a antipsychotic of the butyrophenone class. Quick absorption, high bioavailability, high plasma protein binding rate and other advantages, it has a strong blocking effect on dopamine receptors, not only can improve the dopamine in the brain of patients It can also play a better role in anti-excitement, anti-hallucination, and antiemetic effects. In addition, the drug is metabolized by the human liver and has less impact on the human body. It has fewer adverse reactions than other anti-Parkinson’s disease drugs, and its clinical drug safety is relatively high.

Haloperidol can help patients improve their anxiety and depression to a certain extent , Mental state and degree of cognitive impairment, etc. Its adverse reactions are less, which is beneficial to help patients maintain stable disease and promote the recovery process, which has promotional value. Studies have shown that Haloperidol has a high bioavailability, and it is mainly metabolized by the liver and less harmful to the human body, but Taking large amounts can cause excessive sedation, dystonia, inability to sit still and many other adverse reactions.

Therefore, when haloperidol is used in combination clinically, its dosage should be carefully considered to ensure its safety in clinical application.

Is the combination of haloperidol and pramipexole helpful?

Fluorine The combined effect of piperidinol and pramipexole is worthy of recognition, It can not only improve the symptoms and mental state of patients, enhance their motor function, but also reduce adverse reactions and improve drug safety , but there is a problem of higher medical expenses, clinically it needs to be recommended in combination with the patient’s personal wishes and economic level.

In general, Haloperidol combined with pramipexole has an outstanding clinical effect in the treatment of Parkinson’s disease with mental disorders and < span>High safety, but the medical expenses are not cheap, so it is better to formulate a specific plan according to the actual situation of the patient.