Dosage of Domperidone

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Indigestion

Indications

Indigestion symptoms caused by delayed gastric emptying, gastroesophageal reflux, esophagitis: epigastric fullness, bloating, epigastric pain; belching, flatulence; nausea, vomiting; Heartburn in the mouth with or without regurgitation of gastric contents [1-4].

For the treatment of digestive disorders (nausea, vomiting, loss of appetite, bloating, epigastric discomfort, abdominal pain, heartburn, belching, etc.) caused by the following diseases or drugs. Adults: Chronic gastritis, gastroptosis, reflux esophagitis, gastrectomy syndrome, the use of anticancer drugs or levodopa, etc.

For indigestion, bloating, belching, nausea, vomiting, abdominal pain [6-7].

▍Dosage

Tablets:

Adult (weight greater than or equal to 35 kg): 10 mg three times a day, no more than 40 mg per day[1].

Adults: Oral, 1-2 tablets at a time (equivalent to 10-20 mg of domperidone), 3 times a day; if necessary, take an additional dose before going to bed[5].

Adults: For the treatment of upper gastrointestinal motility disorders, the usual oral dose for adults is 1 tablet (10 mg) at a time, 3 to 4 times a day, 15 to 30 minutes before meals or at bedtime. For patients with severe disease or developed tolerance, it can be increased to 2 tablets (20 mg) at a time, 3 to 4 times a day [2].

Disintegrating Tablets:

This product does not require water or a small amount of water, and does not need to be chewed. The drug is placed on the tongue, disintegrated quickly, and then swallowed into the digestive tract to take effect. For the treatment of upper gastrointestinal motility disorders, the usual oral dose for adults is 1 tablet (10 mg) each time, 3 to 4 times a day, 15 to 30 minutes before meals or at bedtime.

For patients with severe disease or developed tolerance, it can be increased to 2 tablets (20 mg) each time, 3 to 4 times a day [3].

Dispersible Tablets:

Oral. Adults take 1 tablet at a time, 3 times a day, 15 to 30 minutes before meals [6].

Capsules:

Adults: For the treatment of upper gastrointestinal motility disorders, the usual oral dose for adults is 1 capsule (10mg) each time, 3 to 4 times a day, 15 to 30 minutes before meals or at bedtime. For patients with severe disease or developed tolerance, it can be increased to 2 capsules (20 mg) each time, 3 to 4 times a day [4].

Suspension:

Oral. Adults take 10 mL at a time, three times a day, 15 to 30 minutes before meals [7].

Nausea, Vomiting

▍Indications

Nausea, vomiting due to functional, organic, infectious, dietary, radiation therapy, or chemotherapy. The use of dopamine receptor agonists (such as levodopa, bromocriptine, etc.) to treat nausea and vomiting caused by Parkinson’s disease is a specific indication for this product [1-4].

For the treatment of digestive disorders (nausea, vomiting, loss of appetite, bloating, epigastric discomfort, abdominal pain, heartburn, belching, etc.) caused by the following diseases or drugs. Adults: Chronic gastritis, gastroptosis, reflux esophagitis, gastrectomy syndrome, the use of anticancer drugs or levodopa, etc.

▍Dosage

Tablets:

Adult (weight greater than or equal to 35 kg): 10 mg three times a day, no more than 40 mg per day[1].

Adults: Oral, 1-2 tablets at a time (equivalent to 10-20 mg of domperidone), 3 times a day; if necessary, take an additional dose before going to bed[5].

For nausea and vomiting caused by taking anti-Parkinsonian dopamine receptor agonists, adults can take 2 tablets (20 mg) orally, 3 to 4 times a day. Such as nausea and vomiting caused by intravenous anti-Parkinson’s dopamine receptor agonists, the therapeutic dose needs to be increased [2].

Disintegrating Tablets:

For nausea and vomiting caused by taking anti-Parkinson’s dopamine receptor agonists, adults can take 2 tablets (20 mg) orally, 3 to 4 times a day. For nausea and vomiting caused by intravenous antiparkinsonian dopamine agonists, the therapeutic dose needs to be increased [3].

Capsules:

For nausea and vomiting caused by taking anti-Parkinsonian dopamine receptor agonists, adults can take 2 capsules (20 mg) orally each time, 3 to 4 times a day. Such as nausea and vomiting caused by intravenous anti-Parkinson’s dopamine agonists, the therapeutic dose needs to be increased [4].

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