Another antihypertensive drug was recalled because of excessive carcinogens, this time not sartan

Hypertension is a debilitating disease that can lead to more complications if left untreated. Such as coronary heart disease, angina and myocarditis. The vast majority of hypertensive patients must adhere to long-term medication to avoid a vicious circle. Middle-aged and elderly people over the age of 60 should regularly monitor their blood pressure.

There are many types of antihypertensive drugs, and the therapeutic effect is obvious. Among them, the antihypertensive drugs of sartans and puli are widely used. However, it has been reported recently that the Puli antihypertensive drugs were recalled by the relevant departments, mainly because the drugs contained excessive carcinogens. So what exactly happened? This article elaborates.

First, the reason for the recall of antihypertensive drugs

antihypertensive drugs are also called As an antihypertensive drug, it is mainly used to treat hypertensive diseases. The main principle of antihypertensive drugs is to exert their efficacy by affecting the sympathetic nervous system and the renin-angiotensin-aldosterone system to produce certain physiological regulation effects on blood pressure. Different types of antihypertensive drugs have different components, and the final therapeutic effect varies from person to person.

Puri antihypertensive drugs are angiotensin-converting enzyme inhibitors, known as ACEI drugs. Common drugs are captopril, enalapril, benazepril, cilazapril, ramipril, and perindopril. The above drugs have been used for decades in drug application, and the antihypertensive effect is very significant.

However, in recent years, Puli antihypertensive drugs have been compulsorily recalled by other national departments one after another. The main reason is that some carcinogenic substances will be produced in the process of drug production, and long-term entry into the human body will easily cause direct damage to the body’s organs and tissues. A substance-N-nitrosodimethylamine is often detected during random inspection by these national quality inspection departments. This substance can be fatal if consumed in large quantities.

Compared with foreign countries, the management of drugs in my country is very strict, so the majority of patients can use Puli drugs with confidence and other types of blood pressure medications. In the process of using antihypertensive drugs, it is necessary to insist on taking it for a long time and control the blood pressure within a reasonable range in order to effectively avoid damage to target organs.

Second, the main role of antihypertensive drugs

There are many drugs for the treatment of hypertension ,Common drugs include calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, diuretics and beta-blockers. In addition, patients with hypertension have different degrees of disease, and the treatment should follow an individualized treatment plan to achieve the best drug effect.

Calcium channel blockers inhibit extracellular calcium ions by blocking calcium ion channels on the membrane of myocardial and vascular smooth muscle cells. internal flow, and ultimately achieve the effect of lowering blood pressure. Representatives include nifedipine, amlodipine, nimodipine and lacidipine. In addition to its antihypertensive effect, the drug can also be used to treat coronary heart disease and angina pectoris.

ACE inhibitors can lower blood pressure and improve cardiac function. Especially in patients with hypertension and heart disease, the antihypertensive effect is obvious. At the same time, the drug also has the effect of protecting the kidney, reducing urinary protein and promoting vascular activity. However, it should be used with caution in patients with severe renal insufficiency and renal artery stenosis.

Angiotensin II receptor antagonists are also a class of clinical antihypertensive drugs. It mainly inhibits the binding of angiotensin II to other receptors to relieve blood vessels and reduce peripheral resistance, thereby achieving the effect of lowering blood pressure. If the patient suffers from severe hepatic and renal insufficiency, it should be used under the guidance of a physician, and the individual’s renal function and serum potassium should be monitored at the same time.

Diuretics are divided into potassium-sparing diuretics and potassium-sparing diuretics. Diuretics inhibit blood absorption and dilate blood vessels. It can inhibit the reabsorption of water and sodium by the renal tubules, and reduce the sodium ions on the vascular smooth muscle cells, which reduces the smooth muscle’s ability to respond to contractile substances, and finally achieves a good therapeutic effect.

β-blockers selectively bind to β-adrenergic receptors, thereby antagonizing the effects of neurotransmitters and catecholamines on β-receptors. The body produces a certain agonistic effect, and finally achieves the effect of lowering blood pressure and protecting the cardiovascular system. Commonly used drugs are metoprolol, atenolol, bisoprolol, and labetalol.

Third, how to take it in the safest and most effective way

1 , long-term use. Hypertensive patients need to take antihypertensive drugs for a long time. Hypertension is a chronic disease that easily leads to irreversible changes in the heart, kidneys and brain organs, so insisting on taking medication is the first principle. In addition, when blood pressure is reduced to a reasonable range, it should be considered to increase or decrease the dose of drugs to reduce the degree of harm to the body.

2. Choose the right time. Taking antihypertensive drugs at the right time can maximize the absorption rate of the drug. According to the law of blood pressure changes, the vast majority of hypertensive patients should choose to take medicine in the morning. In addition, due to the relatively high blood pressure during the day, taking it during the day can maintain a higher blood concentration.

3. Combination medication. Combination therapy is generally for some patients with poor treatment effect. Only relying on one drug cannot achieve the desired effect, it must be used in combination with multiple antihypertensive drugs. Puli drugs should be used together with dipine antihypertensive drugs, and combined use can reduce some adverse reactions. such as lower extremity edema.

4. Pay attention to side effects. The main function of antihypertensive drugs is to lower blood pressure, but unscientific medication can cause side effects. Such as dizziness, headache, nausea and vomiting, numbness of limbs and heart palpitations, etc. Therefore, you should pay attention to the dosage of the drug, and do not overdose at one time. Especially those over the age of 65.

4. Do I still need to continue taking medication when blood pressure drops to a reasonable range?

The vast majority Hypertensive patients are classified as primary hypertension. As long as you choose the right drug for treatment, you can lower your blood pressure. But once you stop taking your blood pressure medication. Blood pressure will rise immediately. At present, most of the antihypertensive drugs last for about a day, so after one day, the effect is basically ineffective.

Experiencing blood pressure fluctuations for extended periods of time can cause more physical harm. Therefore, patients must choose antihypertensive drugs according to their actual situation and insist on taking them every day. If the medication you are taking is short-lived, less than a day, you should take it twice or more a day.

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For patients with recurrent high blood pressure, in addition to receiving antihypertensive drugs for treatment, life intervention should also be carried out according to the specific etiology of the disease to achieve better recovery . Patients need to actively manage their health, actively monitor blood pressure changes while taking medication, and make records. Severely ill patients should also go to the hospital for a heart check every six months or a year.

The second antihypertensive drugs are long-acting and short-acting. For patients with chronic hypertension, it is recommended to choose some long-acting antihypertensive drugs. Long-acting antihypertensive drugs can quickly reach the stomach and be absorbed, thus exerting a significant antihypertensive effect. Usually within a few hours after taking the drug, the blood pressure lowering effect begins to show a good effect.

Although long-acting antihypertensive drugs have the characteristics of long-lasting efficacy, small side effects and significant effects. However, patients with high blood pressure also need to take the dose on time and cannot stop taking it without permission. Blood pressure drops to a reasonable range, If you need to stop taking it, you should inform your doctor in advance, and you should also observe your personal changes every day, just in case.

In addition, the patient’s blood pressure is temporarily elevated, and antihypertensive medication should be administered immediately. Generally speaking, a good antihypertensive effect can be achieved 15-30 minutes after taking the drug. Continuing to take it for 10-14 days can effectively improve the condition of high blood pressure. Elderly people may experience side effects after taking antihypertensive drugs and should take appropriate body positions to relieve them.

5. Five common cancer-causing foods

1. Spices. Spice is carcinogenic. A certain amount of chemical components will be added in the production process of spices. These chemical components will be deposited in the human body for a long time and cannot be normally eliminated from the body, which will cause indirect damage to the organs. In addition, spices are basically made from plant raw materials, and the quercetin contained in plants may increase the risk of bowel cancer and bladder cancer.

2. Fried food. Fried foods carry a high risk of cancer. Fried food contains a lot of polycyclic aromatic hydrogen substances, which are carcinogenic chemicals; long-term excessive consumption can cause cancer. In addition, fried food can also lead to the appearance of obesity, and obesity can increase the risk of cardiovascular and cerebrovascular diseases by at least 2-3 times.

3. Moldy food. Moldy food is rich in aflatoxin, and excessive consumption can directly lead to shock or death. Aflatoxin can cause certain damage to liver function, weaken the activity of liver cells, and eventually lead to liver cancer. Therefore, it should be forbidden to eat some moldy food in life. Such as moldy peanuts, corn, and bread.

4. Pickled products. Pickled products contain a lot of nitrates, and eating too much can increase the risk of stomach and stomach cancer. Eating some pickled vegetables for a long time is easy to form calcium oxalate, which will increase the burden on the kidneys and lead to kidney cancer over time. The treatment of kidney cancer is a relatively complex process, and the mortality rate of advanced kidney cancer is very high.

5. Repeatedly boiled water. Repeatedly boiled water has a certain risk of cancer.It is easy to produce nitrite if the water is repeatedly re-boiled After entering the human body, nitrosamine is formed, which eventually leads to cancerous changes in body organs.

Six, preventing high blood pressure

< p data-track="36">Prevention of high blood pressure must start from life and diet, establish a good and good schedule, and eat regularly.In addition Patients should be active and avoid drug abuse. High blood pressure can be well prevented by doing the above.

A good daily life is of great significance to health. Individuals should maintain habits such as staying up late, sitting for a short time, and reducing smoking and drinking, while not participating in bad entertainment such as games or gambling for a long time Activities, so that the body and mind are in a state of relaxation, so as to achieve the purpose of disease prevention. In addition, the elderly should maintain at least 8 hours of sleep time.

Avoid overeating, as well as sweets and greasy foods in your diet. Try to have a varied, light and varied diet for three meals a day. Eat more fresh fruits and vegetables. Fruits and vegetables contain a lot of trace elements, which can fully ensure the nutritional intake of patients. Such as grapes, apples, kiwi and pears.

Active physical activity can be effective in improving physical fitness. Doing aerobic exercise two or three times a day can promote gastrointestinal motility and blood circulation, and at the same time can improve personal immunity and resistance level, and reduce bacterial infection. Scientific research has confirmed that reasonable exercise has a certain function of lowering blood pressure, so it is very suitable for patients with hypertension to exercise.

Prevention of high blood pressure requires avoiding drug abuse. Drug abuse can exacerbate the decay of organs and also cause damage to the walls of blood vessels. Therefore, it is necessary to take reasonable medication. Especially hormonal drugs, do not take them casually.

Summary:

There are many complications of high blood pressure, which can easily cause damage to body organs, and even cause death in severe cases. Therefore, antihypertensive drugs should be actively used to relieve the symptoms caused by hypertension and avoid further damage to target organs. In addition, it is necessary to maintain a good attitude during treatment and avoid unscientific medication habits.

Pril-like antihypertensive drugs have significant blood pressure lowering effect . However, some foreign countries were eventually recalled due to production quality problems. Mainly because the drug contains the carcinogen-N-nitrosodimethylamine. Long-term overdose not only damages body tissues and organs, but also induces cancer. Therefore, you should consult your doctor before using the drug.