5 types of common kidney diseases, uremia risk ranking released! Unexpected outcome

Among the causes of uremia, chronic glomerular injury type nephropathy currently occupies the second place, accounting for about one third.

Clinically, glomerular nephropathy is also one of the more common nephropathy. About half of ten patients have clear glomerular disease. In the early stage, the symptoms of urinary occult blood and urinary protein are mostly manifested.

Will fibrosis in glomeruli lead to renal failure?

Comparatively speaking, the decline of renal function caused by glomerular damage is a type that is relatively easy to control. There is almost no glomerular fibrosis found in the early stage, the renal function damage is relatively mild, and the progress is slow. Timely diagnosis and treatment have a certain chance of recovery and no recurrence. In the mid-term, some glomeruli develop fibrosis and sclerosis, and develop to the stage of renal insufficiency, but generally the damage is not half, and the renal function still plays an active role, which is relatively easy to control, but it is necessary to be alert to repeated recurrence, which will lead to further deterioration and renal failure. Condition.

Although it is irreversible once substantial damage to the kidneys occurs, it is controllable. The presence of fibrosis in the glomerulus does not necessarily mean that renal failure will occur. It must be determined by the overall control situation. Some of these patients have remained stable in the middle stage of renal disease for more than 20 years without any signs of renal failure.

As long as it is strictly controlled, the risk of uremia will not be high even if it develops to the middle stage.

Which kidney diseases are the types of glomerular damage?

The top five most common kidney diseases include:

  • Lupus nephritis

The active systemic lupus erythematosus destroys the autoimmune system and also affects the kidney tissue, resulting in renal damage. The development from mild to severe generally goes through six stages, namely, stage 1 is normal or minimal disease stage; stage 2 is mesangial proliferative type; stage 3 is focal proliferative type; stage 4 is diffuse proliferative type; stage 5 is mesangial. , basement membrane hyperplasia at the same time; severe sclerosis occurs in the most serious stage 6.

Lupus nephritis also has symptoms such as proteinuria and hypertension. Under standardized treatment in the early stage and regular follow-up, the overall prognosis is good. Only a small number of patients are prone to uremia after recurrence of the disease, requiring dialysis or kidney transplantation.

  • Idiopathic Membranous Nephropathy

The clinical manifestations are often nephrotic syndrome dominated by massive proteinuria, edema, and hypoalbuminemia. It has a certain self-healing property, and about 20%-30% of patients can spontaneously relieve without treatment. Relatively speaking, the overall progress of the disease is relatively slow, and urinary protein and hypertension are the main factors affecting the progress of renal function.

  • Minimal disease

Most common in children, A small number of adults are also affected. Typical symptoms are also massive proteinuria, high edema, and hypoalbuminemia. It is more sensitive to hormone response. After 4 weeks of taking the drug, the urine protein of the pediatric patients is significantly reduced, and some people can turn negative. Adults take longer. The key to the prevention and treatment of uremia is to prevent recurrence, and each recurrence will accelerate the further development of renal function.

  • IgA nephropathy

Affects the progression of IgA nephropathy The main factors are urine protein, blood pressure, serum creatinine, genetic and pathological factors. If stage glomerulosclerosis and renal tubular atrophy and fibrosis have been detected, it indicates that the pathological type is severe and the risk of renal function deterioration is higher. high.

  • Focal segmental glomerulosclerosis

It is mainly a pathological morphology of the kidney, which is characterized by focal and segmental damage to the glomerulus, which is simply a local damage.

The risk ranking of five types of nephropathy and uremia is released! Unexpected results

A previous in-depth study looked at the risk of developing uremia in five types of kidney disease.

Patients enrolled in the study met these criteria:

Mean glomerular filtration rate (eGFR) was at About 60 mL/min/1.73 m2, the average age is 43.5 years old, the ratio of male to female is almost one to one, and the number of people is half.

After nearly five years of follow-up research, it was found that:

1. Focal segmental glomerulosclerosis type nephropathy The glomerular filtration rate decreased the most , decreasing by about 1.8 mL/min/1.73 m2/ year.

Membranous nephropathy and IgA nephropathy were second, both at 0.8 mL/min/1.73 m2/, and the decline rate of minimal change disease and lupus kidney was relatively slow.

2. From the perspective of the rate of glomerular filtration rate decline, the highest risk of uremia is undoubtedly focal segmental glomerulosclerosis type nephropathy.

Followed by IgA nephropathy, lupus nephritis, membranous nephropathy and minimal change nephropathy.

It can be seen from this that the decrease of glomerular filtration rate can indicate the basic condition of the disease. Even if some types of nephropathy begin to have severe pathology, as long as the control is stable, the urine protein can be maintained. , blood pressure and other stable, the risk of uremia naturally decreased.

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